Game #1 (Airs: Nov. 27): Enloe / Nash Central

Game #2 (Airs: Dec. 4): Raleigh Charter / Triangle Math & Science Academy

Game #3 (Airs: Dec. 11): Middle Creek / Smithfield-Selma

Game #4 (Airs: Dec. 18): East Chapel Hill / Pinecrest

Game #5 (Airs: Dec. 25): Cape Fear Christian Academy / NC School of Science & Math

Game #6 (Airs: Jan. 1): Heritage / Rocky Mount

Game #7 (Airs: Jan. 8): Durham School of the Arts / Longleaf School of the Arts

Game #8 (Airs: Jan. 15): Southside Christian School / Triangle Math & Science Academy

Game #9 (Airs: Jan. 22): Edgecombe Early College / Research Triangle

Game #10 (Airs: Jan. 29): North East Carolina Prep / Wake Forest

Game #11 (Airs: Feb. 5): Broughton / Jordan-Matthews

Game #12 (Airs: Feb. 12): Apex Friendship / North Wake College & Career Academy

Brain Game Playoffs 2022, Round 1

Apex Friendship v. Triangle Math & Science, airs Feb. 26

NCSSM v. Broughton, airs March 5

Smithfield-Selma v. Raleigh Charter, airs March 12

Enloe v. NEC Prep, airs March 19

East Chapel Hill v. Durham School of the Arts, airs March 26

Research Triangle v. Rocky Mount, airs April 2

Brain Game Playoffs 2022, Round 2

Enloe v. Smithfield-Selma, airs April 9

East Chapel Hill v. NCSSM, airs April 16

Apex Friendship v. Research Triangle, airs April 23

Brain Game Final Four

All three Round 2 winners, plus one wild card team, advance to the Final Four.

• Brain Game Playoffs: East Chapel Hill v. NCSSM
• Brain Game Final Four: Enloe HS vs Apex Friendship
• Brain Game playoffs: Apex Friendship vs. Research Triangle
• Brain Game: East Chapel vs. Selma-Smithfield

The two winners of the Final Four matches will play the Championship game.